MSC Secretome

1. MSC Secretome Composition

1.1. Soluble Factors

1.1.1. Growth factors

1.1.1.1. VGEF

1.1.1.2. FGF

1.1.1.3. HGF

1.1.2. Soluble factors

1.1.2.1. Adenosine

1.1.2.2. Lactate

1.1.3. Protein

1.1.3.1. TGF-β

1.1.3.2. IL-10

1.1.4. Antioxidants

1.1.4.1. SOD

1.1.4.2. GSH

1.2. Extracelluar Vesicles

1.2.1. Exosomes

1.2.2. Microvesicles

2. Lung Diseases

2.1. Chronic obstructive pulmonary disease (COPD)

2.2. IPFIdiopathic pulmonary fibrosis (IPF)

2.3. Acute Respiratory Distress Syndrome(ARDS)

2.4. Acute Lung Injury (ALI)

3. MSC Sources

3.1. Bone Marrow

3.2. Adipose derived MSCs

3.3. Umbilical Chord MSCs

4. MSC Secretome Preperation

4.1. Culture Conditions

4.1.1. Hypoxia

4.1.2. Starvation

4.1.3. LPS Preconditioning

4.2. Mechanical Stimulation

4.3. Media Supplimentation