1. Floriquinolones
1.1. Examples
1.1.1. Ciprofloxacin
1.2. Organism coverage
1.2.1. Broad spectrum
1.3. Indications
1.4. Adverse reactions
1.4.1. Damage to weight bearing joints, Tendonitis
1.5. Contraindications
1.5.1. Children, elderly, pregnant and breastfeeding,
1.6. Drug interactions
1.6.1. Convusions with NSAIDs
2. Cephalosporins
2.1. Examples
2.1.1. First generation (CEFA)
2.1.1.1. Cefalexin
2.1.1.2. Cefadroxil
2.1.1.3. Cefradine
2.1.2. Second generation (
2.1.2.1. Cefuroxime
2.1.2.2. Cefaclor
2.1.3. Third Generation
2.1.4. Fourth Generation
2.2. Organism coverage
2.3. Indications
2.3.1. 1st and 2nd gen for UTIs unresponsive to first and second line treatment
2.4. Adverse reactions
2.4.1. Colitis
2.4.2. Hypersensitivity reactions
2.5. Contraindications
2.6. Drug interactions
3. Clindamycin (bacteriostatic)
3.1. Organism coverage
3.1.1. Narrow spectrum
3.2. Indications
3.2.1. Staphylococcal infections inc MRSA
3.3. Contraindications
3.4. Drug interactions
3.5. Adverse reactions
3.5.1. Colitis. STOP if diarrhoea
4. Metronidazole
4.1. Organism coverage
4.1.1. Useful against anaerobic organisms
4.1.2. Narrow spectrum
4.2. Indications
4.2.1. Gingivitis
4.3. Adverse reactions
4.3.1. Nausea and vomiting
4.4. Contraindications
4.4.1. Not suitable in children, pregnancy or BF
4.5. Drug interactions
4.5.1. Alcohol
4.5.1.1. Disulfaram-like reaction (flushing of face anbd skin)
5. Penicillins
5.1. Examples
5.1.1. Ampicillin
5.1.2. Amoxicillin
5.1.3. Flucloxicillin
5.1.3.1. Cholestatic Jaundice
5.1.4. Co-amoxiclav
5.1.5. Penicillin V
5.1.6. Benzylpenicillin
5.2. Organism coverage
5.2.1. Broad spectrum
5.3. Indications
5.4. Adverse reactions
5.4.1. Allergy ~ 10%
5.4.2. Anaphylaxis ~0.05%
5.4.3. Toxic intrathecally
5.5. Contraindications
5.6. Drug interactions
5.7. Excretion
5.8. Suitability
5.8.1. suitable in pregnancy and breastfeeding
6. Macrolides
6.1. Examples
6.1.1. Erythromycin
6.1.2. Clarithromycin
6.1.3. Azithromycin
6.2. Organism coverage
6.2.1. broad spectrum
6.3. Indications
6.4. Adverse reactions
6.4.1. QT prolongation, Nausea and vomiting
6.5. Contraindications
6.5.1. Arhythmias,
6.6. Drug interactions
6.6.1. SICKFACES.COM
6.6.1.1. Warfarin
6.6.1.2. Statiins
7. Aminoglycosides (bactericidal)
7.1. Examples
7.1.1. Gentamicin
7.2. Organism coverage
7.2.1. Broad spectrum
7.3. Indications
7.3.1. Septicaemia, Endocarditis, Pyelonephritis, Serious Infections
7.4. Adverse reactions
7.5. Contraindications
7.5.1. Elderly, pregnancy, breastfeeding
7.6. Drug interactions
7.7. Excretion
7.8. Suitability
8. Tetracyclines (bacteriostatic)
8.1. Examples
8.1.1. Doxycycline
8.1.2. Tetracycline
8.1.3. Oxytetracycline
8.2. Organism coverage
8.2.1. Broad spectrum
8.3. Indications
8.3.1. Respiratory infections
8.4. Adverse reactions
8.4.1. Harm healthy bone growth, stain teeth, photosensitivity reactions
8.5. Contraindications
8.5.1. children under 12, pregnant women, breastfeeding women, renal impairment (except doxy and Mino)
8.6. Drug interactions
8.6.1. Mg, Al, Ca : Absorbption decrease
8.7. Suitability
8.8. Excretion
8.8.1. Renally
9. Narrow Spectrum UTI
9.1. Trimethoprim
9.1.1. Indications
9.1.2. ADRs
9.1.2.1. HYPER K+
9.1.2.2. Blood dyscrasias with long-term use
9.1.3. Contraindications
9.1.3.1. Pregnancy
9.1.3.1.1. Teratogenic
9.1.4. Drug interactions
9.1.5. Excretion
9.1.6. Suitability
9.2. Nitrofurantion
9.2.1. Indications
9.2.1.1. Uncomplicated UTI
9.2.1.1.1. 3 days women
9.2.1.1.2. 7 days men
9.2.1.2. UTI prophylaxis long-term
9.2.2. ADRs/ SE
9.2.2.1. Nausea and vomiting
9.2.2.2. Yellow/ brown urine
9.2.3. Contraindications
9.2.3.1. Pregnant, breastfeeding,
9.2.4. Drug interactions
9.2.5. Excretion
9.2.6. Suitability
10. Glycopeptides
10.1. Examples
10.2. Organism coverage
10.3. Indications
10.4. Adverse reactions
10.5. Contraindications
10.6. Drug interactions
11. Glycopeptides (bactericidal)
11.1. Examples
11.1.1. Vancomycin
11.2. Organism coverage
11.3. Indications
11.4. Adverse reactions
11.4.1. Nephrotoxicity
11.4.2. Ototoxicity
11.4.3. Red-man syndrome
11.4.4. Blood dyscrasias (measure full blood count)
11.4.5. Skin disorders (Steven-johnson's syndrome)
11.4.6. Rash
11.5. Contraindications
11.6. Drug interactions
11.6.1. NARROW TI