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Selank by Mind Map: Selank
0.0 stars - reviews range from 0 to 5

Selank

Experiences

Ray Bonior Experiments

Interactions, Uridine (UMP)

Current Duration of Experiment: 16 weeks, took a week off to cycle in the happy stack

Selank supplied by ceretropic, combined with mannitol to increase BBB permeability

Personal Discoveries for best practice, Dose 250-500mcg, Best feeling AND performance 24-48hrs after dose, Optimum results dosing 2 days in a row followed by 5 day break, Selank is better preserved in methylparaben BAC for injection, avoid benzyl alcohol sensivity, Selank has to be put to use in order to get max nootropic effect, all top lumosity scores while on selank stack, better memory and fluid intelligence from brain exercises + selank stack, Doing brain exercises/studying during acute effects yields better results during after effects., Selank has a paradoxical effect on my ADHD, intranasal administration is not that much more convenient than subq, prefer subq, painless with insulin needles

Factors that may make my experience different from that of a "healthy" individual, Mal de Debarquement Syndrome, *currently not expressing symptoms, ADHD-PI, paradoxical reactions to many drugs, caffeine makes me tired after a quick rush, racetams suck, magnesium makes me feel doped, coming direct;y from 1+ yrs of continuous happy stack, Binocular Vision Disorder?

Synergies, [Stack] uridine (UMP) when cycled NOT concurrently, better results from both stacks when cycled, n-acetyl l-tyrosine (NALT), phospatidylserine (PS), semax, found semax to be unsustainable, Depression, Irritiability, Better memory

My experience, Typical timing of effects, 00:00, immediate endorphin rush from injection. Nothing related to the medication, take NALT, 00:05, Start to feel a calm, 00:30, full acute effects, relaxed, calm, focused, Brain games become easier, Stress reduction, Amazing sex, 2:00, visual effect, vision starts to vacillate between normal and HD, Best visual effect when taken with NALT., 4:00, visual effect permanent, 12:00, sleepy, 24:00 +, After-effects, Happy, energetic, easier memory recall, less ADHD, Anhedonia not present, Mindfullnes feels like a built-in feature, Still synergistic, with NALT, with PS, 72:00 Effects slowly wear off, Effects, Memory, Increase in both working and long-term memory, Focus, Calm focus allows me to complete tasks without procrastination. I'm less distracted by random thoughts., IQ, I can strategize and quickly/dynamically analyze multidimensional problems easier., Chess rank went up by 300-400 points during the selank trial without studying moves. All result of on the spot strategy. Chess frequency did not increase., PresentMindfulness, Mindfullness (state of flow) is easier to obtain, Mood, Happy with a marked reduction in anhedonia. Calm confidence to tackle tasks., Best mood experienced 24-48 hrs after acute effects., Empathy, definitely a heightened awareness of others needs and point of view. My GF certainly appreciated this aspect., Libido, Sex is absolutely amazing during the acute effects of selank, Interest in sex diminishes as the acute effects wear off., Visual, Perhaps the most important effect for me. My vision has never been better and has eliminated a great deal of brain fog/confusion due to unbalanced focus, Better vision persisted after a few weeks after trial going back to happy stack, Smell, Not sure this is a positive effect, but in the beginning I had the nose of a blood hound., Quantified, Chess rank increased 300 points avg., All of my top scores on lumosity were during selank trials

Stack, Tryptophan, Night before, NALT, with AM dose, PS, with PM dose, raw cacao powder, with all doses, with ON double rich chocolate protein (mmm), co-factors, Thorne Research Basic Nutrients, D3, 5MTHF, 400mcg additional, Stack notes:

Medievil's selank trial (longecity)

MetabolicAlchemy's 10 day trial

more isn't better

Selank review by alarang

Research

enkephalin-opioid system

The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank, The data obtained reveal a new target for selank in CNS and indicate significance of the activity of enkephalin-opioid system in individual sensitivity to selank.

Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system., It is hypothesized that the revealed behavioral effect of selank is mediated by its modulating effect on the endogenous opioid system and specifically, by its effect on activity of enkephalin-degrading enzymes.

The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity., reduced total enkephalinase activity in the blood during generalized anxiety, attenuates behavioral anxiety reactions and does not cause side effects typical of most anxiolytics, Selank was more potent than peptidase inhibitors bacitracin and puromycin in inhibiting enkephalinases

Inflammation

Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank., participation of Selank in the processes of regulation of inflammation in the body

Anxiolytic/Antidepressant

Compensatory and antiamnestic effects of heptapeptide Selank in monkeys, Selank effects do not depend on the type of neurotic disturbances and have long-term compensatory character. Selank is a promising agent for correction of various psychoemotional disturbances (alarm-and depression-like disorders)

[Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice]., possesses an anxiolytic and psychostimulant effect, antidepressant component in the spectrum of neuropsychotrophyc activity of selank

Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo

Memory/Learning

Transcriptome alteration in hippocampus under the treatment of tuftsin analog Selank, Selank is able to regulate ion homeostasis of hippocampal cells and thereby modulate different ion-dependent processes, which include the processes of learning and memory formation.

The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats., potential for its use in optimizing mnestic functions in conditions of elevated emotional tension.

monoamine

[Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA].

Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study

immunomodulation

[Changes in expression of the genes for chemokines, cytokines, and their receptors in response to selank and its fragments], Selank exerts anxiolytic and nootropic effects and, on the other hand, has pronounced antiviral properties.

The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action., Selank and its short fragment Gly-Pro influence the expression of genes that mediate different types of immune responses, thereby maintaining the balance of the immune system.

alcohol withdrawal

Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation

neuropeptide regulaiton

Effect of selank on the main carboxypeptidases in the rat nervous tissue, The preparation has been shown to cause long, preserved for 24 h changes of activities of these carboxypeptidases. It is suggested that the change in activity of the studied enzymes can be one of mechanisms of regulation of level of neuropeptides at action of selank.

Pharmacology

Russian Info (selank website) [translated]

individual actions

complexity and duration

the duration of the aftereffect -

Routes of Administration (RoA)

intranasal

subcutaneous

intramuscular

Mechanism of Action (MoA)

inhibits degradation of enkephalins and other endogenous regulatory peptides, (APN) Aminopeptidase N, (NEP) Neutral endopeptidase, (DPP3) Dipeptidyl peptidase 3, (CPA6) Carboxypeptidase A6, (ACE) Angiotensin-converting enzyme

activation of the brain monoaminergic systems

dopamine synthesis and turnover

modulation of the tyrosine hydroxylase activity

Genetic alteration

induce metoblism of serotonin

immunomodulation

Other

anolgue of tuftsin

history

russian name Селанк

Institute of Molecular Genetics of the Russian Academy of Sciences

As of 2010, the drug has completed stage III clinical trials in Russia

Developed in the early 80's

Important note on Selank

[Google Translated] from Russian to English. Being human neuropeptide, Selank's effect on the body as "endogenous expert": exactly the extent and such a direction as to what is necessary to maintain and / or restore the normal functioning of the central nervous system of each individual , weakened or impaired as a result of the impact of adverse factors. The more developed pathological conditions, the stronger the "expert" action of Selank. Conversely, the healthier state of the central nervous system, the effect is less pronounced Selank who can not find, in this case, the objects to be restored. The presence of Selank normalizing effect on activity of the major neurotransmitter systems of the brain determines the plasticity of its pharmacological and therapeutic effects. In patients with generalized anxiety disorder in the spectrum of action Selank marked anxiolytic effect; in patients with neurasthenia more pronounced stimulating effect of the drug antiastenicheskoe. Thus, Selank is the first representative of a class of "smart" drugs. On the basis of studies have shown that pluripotency and diversity effects Selank (eg. Effect on the activity of serotonergic, catecholaminergic and opiatergicheskoy systems and so on.), Largely due to the inclusion of them in the cells of the brain biochemical cascade processes, prolong and reinforce the therapeutic effect of the drug.

TL;DR It doesn't work as well in healthy individuals.

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