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Prodromal symptoms by Mind Map: Prodromal symptoms
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Prodromal symptoms

Is there a relation between anosmia and autonomic dysfunction?

in PD there is (Goldstein 2009)

Is there a relation between RBD and anosmia/hyposmia?

We know about RBD and cognitive dysfunction

We know about RBD and autonomic dysfunction

What's the relative predictive value of the following prodromal symptoms



Autnomic dysfunction

Cognitive dysfunction

What ways can we measure the prodromal symptoms



Autonomic Dysfunction

Cognitive dysfunction

Parkinson's Disease

How do the prodromal symptoms relate to Braak stages?

Patient recruitment

PD Association

Through PD clinic

Inclusion criteria

Relative of PD patient

PD diagnosis by a neurologist / retrospective

Absence of history of (neuropsychiatric) disorders

Absencs of conditions known to influence olfactory function

No medication that might influence dopamine transporter binding and/or olfactory function

Absence of parkinsonism as defined by the UK PD Society brainbank criteria

Cambridge Examination for mental disorders (CAMCOG)

Is it possible to come to a reliable diagnosis when combining the prodromal symptoms?

What is the added value of adding a DAT scan?

When is the optimal time to do a DAT scan?

Can we challenge the "Dual hit hypothesis"?

Is there a relation between Anosmia/hyposmia and cognition?

In PD patients there is no relation

27. Doty, R.L., D.A. Deems & S. Stellar. 1988. Olfactory dysfunction in parkinsonism: a general  deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 38:  1237–1244. 28. Doty, R.L., M.B. Stern, C. Pfeiffer, et al. 1992. Bilateral olfactory dysfunction in early stage  treated and untreated idiopathic Parkinson’s disease. J. Neurol. Neurosurg. Psychiatry 55:  138–142. References found in: Parkinson’s Disease The Dual Hit Theory Revisited. Christopher H.  Hawkes,a Kelly Del Tredici,b and Heiko Braak