Can anti-inflammatory drugs benefit neurodegenerative diseases? - Contra A. Ludolph, Germany

1. ALS

1.1. arguments

1.1.1. positive results in vitro or in experimental animals may not reflect the human diseases

1.1.1.1. Linker et al 2010, experience with copaxone

1.1.1.1.1. effects on mice nice

1.1.1.1.2. no effects on humans

1.1.1.2. other examples

1.1.1.2.1. minocyclin

1.1.1.2.2. pioglitazone

1.1.2. it is an unproven hypothesis that the pathogenesis of neurodegenerative diseases is related to observations mad e in MS

1.1.2.1. neuroinflammation and the blood-brain barrier

1.1.2.1.1. textbook example

1.1.2.2. When should "antiinflammatory" treatment begin?

1.1.2.2.1. MS in the beginning

1.1.2.3. ALS: Don Clevelands suggestion - the pathogenesis is non cell autonomous and different in disease stages

1.1.2.3.1. toxic microglia seems to influence the progression of the clinically apparent disease in mice, but not the onset of the disease (cleveland et al, science 2006)

1.1.3. It is completely unknown whether inflammation contributes to cell damage - it might be beneficial

1.1.3.1. Summary

1.1.3.1.1. neuroinflammation may be bad

1.1.3.1.2. but... it may also be beneficial

1.1.3.1.3. glial biomarker in CSF

1.1.4. neuroinflammation is a dose-dependent phenomenon

1.1.4.1. neuroinflammation is a dose-dependent phenomenon

1.1.4.2. dose-response curve

1.1.4.2.1. Anke Witting

1.1.4.2.2. Riepe

1.1.4.3. ..

1.1.5. Jumping to conclusions may be bad for the patient

1.1.5.1. BDNF + 15% death rate

1.1.5.2. Pentoxyphillin

1.1.5.3. Pioglitazone + 5% death rate

1.1.5.4. Minocyclin - increased functional deterioration

1.1.5.5. Endoxan experience (80ies and 90ies never documented)

1.1.5.6. Lack of effect immunoglobulins (common experience)

1.1.5.7. Unpublished results in ALS of the 80ies/whole body radiation

1.1.5.8. There are a number of non-reported therapeutical experiences

2. Meeting notes by

2.1. Paul de Roos

2.1.1. www.twitter.com/paulderoos

2.1.2. www.paulderoos.com

2.2. Mindmap hosted on

2.2.1. www.neurologytraining.eu

2.2.1.1. Twitter:

2.2.1.1.1. www.twitter.com/trainneurology

2.3. Meeting

2.3.1. Controversies in Neurology

2.3.1.1. Linkt to website

2.3.2. Meeting Overview mindmap

2.3.2.1. Link to mindmap