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Androgens by Mind Map: Androgens
0.0 stars - reviews range from 0 to 5



T -> DHT (active form) via 5 alpha-reductase

Testicular androgens

Secreted by Leydig cells via LH stimulation

Ovarian and adrenal androgens

converted to T peripherally



Growth and maturation of male genitalia and 2nd sexual characteristics

Nitrogen retention, increase muscle strength, bone growth, RBC and erythropoietin production, decreased HDL, Anabolic steroids on work if on a high protein diet and w/ strenuous exercise (need neg N balance)


Binds cytoplasmic receptor, Complex transported to nucleus, Protein transcription

Circulates bound to SHBG or albumin

Excretion via kidney



Growth disturbance, Cause premature closure of epiphysis

Jaundice, hepatitis, hepatic Ca, Oral steroids only! (oxandrolone, methyltestosterone, etc), Echinacea increases risk

Spermatogenesis, Neg feedback on GnRH and FSH

Tendon rupture, Muscle strength increases, but tendon strength doesn't!

serum PSA, Possible FP BPH testing

DD interactions, Bleeding in pts on warfarin, metabolism of oral hypoglycemics


Hypogonadism, HRT

Growth stimulation, In combo w/ GH

Protein anabolic agents, reverse protein loss after trauma, surgery, or prolonged immobilization

Adjunct Tx for breast carcinoma

Endometriosis, Danazol inhibits mid-cycle LH/FSH surge, E production

Hypoactive sexual desire disorder in women


Androgen receptor antagonists


Spironolactone, (also a K-sparing diuretic, but androgen antag too!)

MOA, antagonize T at receptor, Cyproterone also has progestational effect, suppresses LH and FSH to decrease androgen effect

Use, Hirsutism, excessive sexual drive in men, Chemical castration, Prostate cancer

SE, Black box warning: Nilutamide causes interstitial pneumonitis), Gynecomastia and mild hepatotox (Flutamide only)

Reductase inhibitors



MOA, Inhibit 5 alpha-reductase, can't convert T -> DHT

Use, BPH, Male pattern baldness, Finasteride only (Propecia)

SE, Decreased libido and impotence, Possible decrease in risk of prostate ca, Finasteride only


MOA, antifungal that inhibits steroid synthesis

Use, prevent hirsutism in PCOD

Se, Tox limits use, Will turn of synth of ALL steroids, Not good!!


GnRH analogue, Tx for prostate cancer

Saw Palmetto

Relieves Sx of BPH (questionable efficacy)