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Androgens by Mind Map: Androgens
0.0 stars - reviews range from 0 to 5

Androgens

General

T -> DHT (active form) via 5 alpha-reductase

Testicular androgens

Secreted by Leydig cells via LH stimulation

Ovarian and adrenal androgens

converted to T peripherally

Testosterone

Actions

Growth and maturation of male genitalia and 2nd sexual characteristics

Nitrogen retention, increase muscle strength, bone growth, RBC and erythropoietin production, decreased HDL, Anabolic steroids on work if on a high protein diet and w/ strenuous exercise (need neg N balance)

MOA

Binds cytoplasmic receptor, Complex transported to nucleus, Protein transcription

Circulates bound to SHBG or albumin

Excretion via kidney

SE

Masculinization

Growth disturbance, Cause premature closure of epiphysis

Jaundice, hepatitis, hepatic Ca, Oral steroids only! (oxandrolone, methyltestosterone, etc), Echinacea increases risk

Spermatogenesis, Neg feedback on GnRH and FSH

Tendon rupture, Muscle strength increases, but tendon strength doesn't!

serum PSA, Possible FP BPH testing

DD interactions, Bleeding in pts on warfarin, metabolism of oral hypoglycemics

Use

Hypogonadism, HRT

Growth stimulation, In combo w/ GH

Protein anabolic agents, reverse protein loss after trauma, surgery, or prolonged immobilization

Adjunct Tx for breast carcinoma

Endometriosis, Danazol inhibits mid-cycle LH/FSH surge, E production

Hypoactive sexual desire disorder in women

Antiandrogens

Androgen receptor antagonists

Flutamide

Spironolactone, (also a K-sparing diuretic, but androgen antag too!)

MOA, antagonize T at receptor, Cyproterone also has progestational effect, suppresses LH and FSH to decrease androgen effect

Use, Hirsutism, excessive sexual drive in men, Chemical castration, Prostate cancer

SE, Black box warning: Nilutamide causes interstitial pneumonitis), Gynecomastia and mild hepatotox (Flutamide only)

Reductase inhibitors

Finasteride

Dutasteride

MOA, Inhibit 5 alpha-reductase, can't convert T -> DHT

Use, BPH, Male pattern baldness, Finasteride only (Propecia)

SE, Decreased libido and impotence, Possible decrease in risk of prostate ca, Finasteride only

Ketoconazole

MOA, antifungal that inhibits steroid synthesis

Use, prevent hirsutism in PCOD

Se, Tox limits use, Will turn of synth of ALL steroids, Not good!!

Leuprolide

GnRH analogue, Tx for prostate cancer

Saw Palmetto

Relieves Sx of BPH (questionable efficacy)