ANTIPSYCHOTIC (PBL 1)

1. acts on

1.1. Mesolombic

1.1.1. positive symptoms

1.2. Mesocorticol

1.2.1. negative symptoms

1.2.2. affective symptoms

1.3. Nigostriatal

1.3.1. extrapyramidal nervous system

1.3.2. control

1.3.2.1. motor function

1.3.2.2. movement

1.4. Tuberoinfundibular

1.4.1. prolactin secretion

2. DOPAMINE HYPOTHESIS

2.1. "Hyperactivity of DA transmission was responsible for the disorder" (Rossum, 1966)

3. THERAPEUTIC USES

3.1. Psychiatric

3.1.1. schizophrenia

3.1.2. Alzheimer's disease

3.1.3. psychotic depression

3.2. Nonpsychiatric

3.2.1. antiemetic (typical)

3.2.2. relief pruriutus (block H1 receptor)

4. TYPICAL

4.1. example

4.1.1. Chlorpromazine

4.1.2. Fluphenazinedeconate

4.1.3. Haloperidol

4.1.4. Perphezine

4.2. MOA

4.2.1. D2 antagonist

4.3. SE

4.3.1. EPS > metabolic

5. ATYPICAL

5.1. example

5.1.1. Clozapine

5.1.2. Olanzapine

5.1.3. Quetiapine

5.1.4. Asenapine

5.2. MOA

5.2.1. DS & 5HT2A antagonist

5.2.2. dissociate more rapidly from D2 receptor

5.2.3. acute EPS

5.2.4. hyperprolactinaemia

5.3. SE

5.3.1. Metabolic > EPS

6. BEHAVIORAL EFFECTS on schizophrenic patients

6.1. pseudodepression

6.2. akinesia

6.3. confusion