Anti-Psychotic Drugs

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Anti-Psychotic Drugs by Mind Map: Anti-Psychotic Drugs

1. 1st: Typical

1.1. Drugs example

1.1.1. Chlorpramazine

1.1.2. Fluphenazine

1.1.3. Haloperidol

1.1.4. Perphenazine

1.2. MOA

1.2.1. Mesolimbic: Improved + effect ( blocked excessive dopamine )

1.2.2. Mesocotical: Worsening of - effect (blocked decreased dopamine)

1.2.3. Nigrostriatal : EPS symptoms ( dt blocked of D2 receptor)

1.2.4. Tuberoinfundibulat: Increase Prolactin neuron

1.3. Side effect

1.3.1. Sedation : M1, Miu1, Alpha 1

1.3.2. Diabetes: X, M3

1.3.3. Weight Gain: Miu 1, 5HT2C

1.3.4. Hyperprolactinaemia

1.3.5. EPS effect

2. Overview

2.1. Dopamine pathway

2.1.1. Mesolimbic

2.1.2. Mesocortical

2.1.3. Nigrastriatal

2.1.4. Tuberoinfundibular

2.2. Scizophrenia

2.2.1. excessive dopaminergic pathway

2.2.2. Anti-psychotic drug: block Dopamine receptor

3. 2nd: Atypical

3.1. Drugs Example

3.1.1. Clozapine

3.2. MOA

3.2.1. Serotonin 2A(5HT2A) & D2 receptor antagonist

3.2.2. Mesolimbic: 5HT2A antagonism does not integrate with AP action

3.2.3. Nigrastriatal: Reduce EPS effect

3.2.4. Mesocortical: increase dopamine release to improve cognitive

3.2.5. Tuberoinfundibular: decrease hyperprolactinaemia

3.3. Side Effect

3.3.1. Higher risk of metabolic effect

3.4. Therapeutic Use

3.4.1. Psychiatric

3.4.1.1. Schizophrenia

3.4.1.2. Bipolar disorder

3.4.1.3. Alzheimeir

3.4.1.4. Tairette's syndrome

3.4.2. Non-Psychiatric

3.4.2.1. Anti-emetic

3.4.2.2. Pruritus