Anti-Microbial Medication

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Anti-Microbial Medication by Mind Map: Anti-Microbial Medication

1. Antivirals

1.1. Viruses (In General)

1.1.1. Viral DNA Polymerase Inhibitors Nucleoside Analogue - Prodrugs Aciclovir (G analogue) Valaciclovir Ganiciclovir (G analogue) Famiciclovir (Prodrug of Penciclovir) Penciclovir Non-Nucleoside Analogue Foscarnet Cidofovir

1.2. HIV

1.2.1. Older Drugs Viral RNA Reverse Transcriptase Inhibitor Nucleoside RT Inhibitor (NRTI) - Prodrugs NucleoTide RT Inhibitor (NtRTI) Non-Nucleoside RT Inhibitors (NNRTI) Viral RNA Protease Inhibitors Saquinavir Ritonavir Indinavir

1.2.2. Newer Drugs Fusion Inhibitor Enfurvititide Co-Receptor Inhibitor Maraviroc Integrase Inhibitor Raltegravir

1.3. Hepatitis Virus

1.3.1. Hepatitis B Interferons + Reverse Transcriptase Inhibitors (Many originally developed for HIV)

1.3.2. Hepatitis C Protease Inhibitors ("-previr" suffix) Biceprevir Telaprevir Simeprevir Polymerase Inhibitors Sofosbuvir

1.4. Influenza Virus

1.4.1. M2 Inhibitors (A type only) Amantadine (Symmetrel) Rimatadine (Flumadine)

1.4.2. Neuraminidase inhibitors (A and B type) Zanamivir (Relenza) Inhalation administration Oseltamavir (Tamiflu) Oral administration

2. Antibiotics

2.1. Inhibition of Cell Wall Synthesis

2.1.1. Beta-Lactams Penicillin Narrow Spectrum, Beta Lactamase Sensitive Broad Spectrum, Beta-Lactamase Sensitive Extended Spectrum, Beta Lactamase Sensitive Penicillinase (Beta-lactamase)-Resistant Cephahlosporins Monobactams Carbapenems

2.1.2. Vancomysin - on reserve

2.1.3. Bacitraicin

2.1.4. Cycloserine

2.2. Injury to Plasma Membranes

2.2.1. Polymixin

2.3. Interfere with Protein Synthesis

2.3.1. Lincosamides

2.3.2. Binds to 30S Ribosomal Subunit Competition with tRNA for "A" Site Tetracycline Abnormal condon-anticondon binding -> misreading Aminoglycosides

2.3.3. Binds to 50S Ribosomal Subunit Inhibition of Transpeptidation Chloramphenicol Inhibition of Translocation Macrolides Premature Termination Puromycin Oxazolidinones - Linezolid

2.4. Interfere with Folate Synthesis or Action

2.4.1. Sulphonamides - Inhibits Dihydropteroate Synthetase

2.4.2. Trimethoprim - Inhibits Dihydrofolate Reductase

2.5. Interfere with DNA Synthesis

2.5.1. Fluroquinolones - Targets Topoisomerase II Narrow Spectrum Nalidixic Acid (not fluorinated} Broad Spectrum (newer) Ciproflaxcin Levofloxacin Gemifloxacin

2.5.2. Metronidazole - Binds and Destabilize Bacterial DNA Antiprotozoal Antibacterial

2.6. Interfere with RNA Synthesis

2.6.1. Rifampicin

3. Antifungals

3.1. Polyenes

3.1.1. Amphotericin B

3.1.2. Nystatin

3.2. Azole Agents

3.2.1. Imadazoles Ketoconazole

3.2.2. Triazoles Fluconazole

3.2.3. Broad Spectrum Triazoles

3.3. Allyamine

3.3.1. Terbinafine (Interferes with ergosterol biosynthesis)

3.4. Flucytocine

3.4.1. Antimetabolite pro-drug that inhibits thymidylate synthase

3.5. Griseofulvin

3.5.1. Binds to microtubles and affects mitosis

3.6. Echinocandins

3.6.1. Affects B-(1,3) Glucan Synthase