1. If chromo del- likely del TS or miRNA that targets oncogene transcripts
2. Solid Tumors
2.1. Lymphoma. 90% are B cell
2.1.1. Nonhodgkins Lymphoma
2.1.1.1. Mature Peripheral B cell CA
2.1.1.1.1. Follicular Lymphoma
2.1.1.1.2. Burkitts Lymphoma
2.1.1.1.3. MALT
2.1.1.1.4. ALK+ Lg B cell Lymphoma
2.1.1.1.5. Small Lymphocytic Lymphoma, aka - CLL
2.1.1.1.6. Mantle Cell
2.1.1.1.7. MM
2.1.1.1.8. MGUS
2.1.1.2. Precursor B cell
2.1.1.2.1. B-ALL
2.1.2. HodgkinsLymphoma= Reed Sternberg Cells
3. Blood CA
3.1. Leukemia - (11q23 rearrangements are prominent - MLL gene)
3.1.1. Acute
3.1.1.1. ALL
3.1.1.1.1. Poor Px: t(9;22), 11q23, Hyperdiploidy. Good Px: 12;21, & hyperdiploidy. t(1;19) is another subtype
3.1.1.2. AML
3.1.1.2.1. Good Px w/ t(15;17), inv 16, t(8;21),
3.1.1.2.2. Poor Px = Inv 3, t(6;9), t(9;11)
3.1.2. 5 q abnlty
3.1.2.1. MDS
3.1.2.1.1. 50% w/ cytogeneitc chnages
3.1.2.1.2. BM blasts @ < 20%, but somewhat hypercellular
3.1.2.1.3. Good Px = nl karyotype, Y-, 5q del, 20q del. Don't always have 5q-
3.1.2.1.4. Childhood MDS-Monosomy 7 worse Px then +8 or nl karyotype
3.1.2.2. 5q Syndrome
3.1.2.2.1. del of 5q as only abnlty
3.1.2.2.2. Females have good Px, hypo or nl marrow cellularity
3.1.2.2.3. blasts <5%
3.1.3. Chronic
3.1.3.1. CLL
3.1.3.1.1. -6, -11, -13 (inc freq), -17 (p53 on this chromo - worst Px)
3.1.3.2. CML
3.1.3.2.1. Philidelphia Chromosome t(9;22)- ABL/BCR
3.1.3.2.2. Gleevec
4. Solid Tumors
4.1. Small Round Cell tumors
4.1.1. Lymphoma
4.1.2. Neuroblastoma
4.1.3. PNET/Ewing Sarcoma
4.1.3.1. Sarcoma = CA arising from Muscle, bone, fat, fibrous tissue, PNS, & Vessels
4.1.3.2. 85% of Ewing tunors w/ t(11;22)--> oncogenic chimera...
4.1.4. Rhabdomyosarcoma (RMS)
4.1.4.1. Mesechymal tumor, varying degrees of striated muscle differentiation
4.1.4.1.1. E-RMS = Embryonal
4.1.4.1.2. A-RMS= Alveolar
4.1.5. Synovial Sarcoma
4.1.5.1. t(X;18)& SSX1, SS18, SSX2, SSX4
4.1.6. Desmoplastic Small Round Cell Tumor
4.1.6.1. t(11;22)
4.1.7. Clear Cell Sarcoma
4.1.7.1. t(12;22)
4.2. Liposarcoma
4.2.1. Mixoid Round Cell Liposarcoma
4.2.1.1. t(12;16)
4.3. Low Grade Fibromixoid Sarcoma
4.3.1. t(7;16)
4.4. ExtraSkeletal Myxoid Chondrosarcoma
4.4.1. t(9;22)NR4A3 / EWSR1