Get Started. It's Free
or sign up with your email address
Rocket clouds
Drug targets by Mind Map: Drug targets

1. Major Drug Targets

1.1. Ion Channels

1.1.1. channel blockade

1.1.2. activation of channel

1.2. Classical receptors

1.2.1. Major receptor strucuctures

1.2.1.1. Type 1: ligand gated ion channels

1.2.1.1.1. Ionotropic receptor activation

1.2.1.1.2. pentameric complex of subunits

1.2.1.2. Type 2 G protein coupled receptors

1.2.1.2.1. 7 transmembrane domaines

1.2.1.2.2. ligands include Ach, 5-HT, dopamine, opioids and others

1.2.1.2.3. 3 GPCR subfamilies

1.2.1.2.4. G Protein activation

1.2.1.2.5. Desensitization

1.2.1.3. Type 3 Kinase linked receptors

1.2.1.3.1. one transmembrane domain, form dimer pairs

1.2.1.3.2. signaling initiated by ligand binding followed by dimerization of the receptor

1.2.1.3.3. kinase linked and related receptors

1.2.1.4. Type 4 nuclear receptors

1.2.1.4.1. No transmembrane domain

1.2.1.4.2. ligands include many hormones and vitamins

1.2.1.4.3. effectors are mostly post transcriptional products of gene activation

1.2.1.4.4. Nuclear receptor subfamilies

1.3. Enzymes

1.4. Transporters

1.5. Nucleic acids

1.5.1. targets DNA and RNA metabolism, (inhibits regulatory proteins, direct interaction)

1.5.1.1. Intercalating agents

1.5.1.2. alkylating agents

1.5.1.3. Strand breaking agents

1.5.1.3.1. bleomycin

1.5.2. RNA specific

1.5.2.1. antisense

1.5.2.2. siRNA